We identified 132 Reactome pathways as potential pathways regulated by combined miRNA signature including “Oncogene-induced senescence”, “Signaling by TGF-beta receptor complex”, “Cellular response to stress”, “Toll-like receptor 7/8 cascade”, “Immune system,” and “Innate immune system.” The gene set enrichment analysis results showed this miRNA network regulates multiple pathways involved in cancer and innate immune function. This evidence concerns the gene TLR7 and cancer.