We recently reported that H19 was the highest-expressed ncRNA in PANC-1 lung metastasis-derived human pancreatic cancer cells and that inhibition of H19 decreased the lung and liver metastases of pancreatic cancer in immunodeficient mice [25]; this finding indicates that H19 represents a novel candidate for targeted therapy against pancreatic cancer metastasis. This evidence concerns the gene H19 and familial pancreatic carcinoma.