In this study, we analyzed expression of DDB2 protein in HNSCC tumor tissue microarrays; (1) US-Biomax # HN811a containing 19 cases of tumors, six adjacent normal tissues (NAT), two normal tissues (tongue), triplicate cores per case, and (2) US-Biomax # HN242a containing 9 cases of HNSCCs, and two normal tissues of tongue and larynx in duplicates. This evidence concerns the gene DDB2 and neoplasm.