Transcripts of Versican, Vegf-c, Bcl-2, Mmp-9, Il-6 and KC were up-modulated in pituitaries isolated from transgenic mice (Figure 1G); in in vitro studies, exogenous hCG has been shown to up-modulate transcription and expression of these molecules in cancer cells [18, 20]. This evidence concerns the gene MMP9 and cancer.