Therefore, we speculate that cotreatment with cisplatin and SFI upregulated Mfn2 protein expression in cisplatin-resistant NSCLC cells, which induced mitochondrial outer membrane permeabilization, translocation of Bax from the cytoplasm to the mitochondria, and initiation of cytochrome C release. The gene discussed is CYCS; the disease is non-small cell lung carcinoma.