Aside from its main participation in mitochondrial fusion, mitochondrial morphology, and mitochondrial function [30], dysfunction of this Mfn2 is also linked with an assortment of pathological conditions, such as Charcot–Marie–Tooth disease type 2A, diabetes mellitus type 2, obesity, and cancer [8, 9, 29, 31, 32]. Here, MFN2 is linked to obesity due to melanocortin 4 receptor deficiency.