IRS4 and colorectal carcinoma: To study in more detail the possible association between the increase in IRS-4 and the above-mentioned biochemical parameters in CRC, we calculated the Pearson's coefficient between Δ IRS-4 and the corresponding proteins involved in the IGF-1 receptor signalling cascade and in apoptosis biomarkers from the 20 patients described in Table S1 in Supplementary Materials.