The increase in IRS-4 expression levels observed in CRC samples correlated positively with those corresponding to phosphorylated IGF-1 receptor (tyr 1165/1166) (r=0.84; p<0.0001), AKT (r= 0.69; p<0.002), procaspase 3 (r= 0.77; p<0.0005) and PARP (r= 0,89; p<0.000005). Here, AKT1 is linked to colorectal carcinoma.