In this context, HLA-G 5’-UTR methylation was associated with HLA-G gene silencing (Carosella et al., 2015) and HLA-G 3’-UTR with a common SNP rs1063320 was reported to modulate binding of miRNA-148/152 family and suppress soluble HLA-G expression in asthma (Naidoo et al., 2015). Here, HLA-G is linked to asthma.