In the HLA region, candidate loci for sarcoidosis include HLA genes HLA-A, -B, -DPB1, -DQB1, -DRB1, -DRB3; and non-HLA genes BTNL2, C4, C6orf10, HSPA1L, LTA, NOTCH4, TAP2, TNF, and VEGF. The linkage of class III genes, such as TNF and LTA has been demonstrated with class I HLA-B and class II HLA-DRB1). Here, TNF is linked to sarcoidosis.