CD4 and autoimmune disease: This model highlights the importance of Vav1 adaptor functions in the differentiation of CD4+ T cells into Th1/Th17 subsets and suggests that genetic or acquired alterations in Vav1 signaling could play a major role in susceptibility to many immune-mediated diseases, including autoimmune diseases where Th1/Th17 play a preponderant role, such as MG.