Others have shown that modulation of SNS with electro-acupuncture, effectively lowered the concentration of ovarian nerve growth factor (NGF) (Stener-Victorin et al., 2000a) and improved insulin sensitivity and lipid profile in PCOS animal models (Mannerås et al., 2008; Johansson et al., 2010). The gene discussed is NGF; the disease is polycystic ovary syndrome.