CAMK2G and hydrops fetalis: For instance, chronic “hyper-phosphorylation” of RyR2 by PKA (Marx et al., 2000) and CaMKII (Ai et al., 2005; Curran et al., 2010; Grimm et al., 2015; Pereira et al., 2017) that occurs in HF causes dissociation of FKBP12.6 from RyR2, destabilizes the RyR2 complex and causes functional uncoupling of neighboring RyRs.