Genes encoding the sarcomeric proteins β-myosin heavy chain (β-MHC) and cardiac myosin-binding protein C (cMyBP-C) harbor the majority of HCM-causing mutations in this autosomal dominant disease (Richard et al., 2003; Olivotto et al., 2008; Alfares et al., 2015). This evidence concerns the gene MYBPC3 and autosomal dominant disease.