Our latest study verified that 4 weeks of DMY (250 mg/kg/day) intragastric administration attenuated transverse aortic constriction (TAC) induced myocardial hypertrophy via oxidative stress inhibition and sirtuin-3 (SIRT3) pathway enhancement (Chen et al., 2018c). The gene discussed is SIRT3; the disease is cardiac hypertrophy.