Additionally, the receptors Lrp1, Lrp2 and the transporter P-gp responsible for the clearance of Aβ from the brain (Shibata et al., 2000; Deane et al., 2003; Cirrito et al., 2005) are downregulated in AD pathology (Marques et al., 2013). This evidence concerns the gene LRP1 and Alzheimer disease.