Gene expression changes suggesting endothelial dysfunction in APOB-100 transgenic animals include reduced expression of the homeobox regulator Meox2, and BBB transporters Mfsd2a, Glut1, Lrp2, Abcb1a genes in APOB-100 transgenic brain microvessels may indicate pathomechanisms similar to those observed in conditions of BBB dysfunctions (Zlokovic, 2011; Zhao et al., 2015). Here, LRP2 is linked to endothelial dysfunction.