LRRK2 and Parkinson disease: In 2015, Guo et al. (2015) analyzed 16 SNPs in eight genes and/or loci in a large Chinese cohort and found Rep1, rs356165, and rs11931074 in SNCA gene, G2385R in LRRK2 gene, rs4698412 in BST1 gene, rs1564282 in PARK17, and L444P in GBA gene have an independent and combined significant relationship with PD.