Finally, we selected and validated the clinical predictive value of COL11A1 (collagen alpha-1(XI) chain), GJB2 (gap junction beta-2 protein) and CTRL (chymotrypsin-like protease CTRL-1) with immunohistochemical (IHC) analysis of 46 paired pancreatic cancer and para-cancerous tissue sections. Here, CTRL is linked to pancreatic neoplasm.