POMT1 and muscular dystrophy: In contrast, a mutation in POMT1 and POMT2 in humans and mammals causes a group of congenital muscular dystrophies; the most severe of these autosomal recessive condition is the Walker–Warburg syndrome, which occurs due to reduced O-glycosylation of DAG-α (hypoglycosylation) in post-translational modification [18].