Furthermore, macrophages increased the expression of activation markers (CD80, CD86 and CD40) that was more evident at week 10 after infection (Fig. 4A) while DCs of Treg depleted mice increased the expression of CD86 and CD40 at week 6 and CD80 and CD40 at week 10 after infection (Fig. 4B). The gene discussed is CD86; the disease is infection.