Knockdown of THRα1 or THRα did not alter the sensitivity to dronedarone for any of the cell lines tested, with similar dose response curves observed for siTHRα1 and siTHRα compared to their respective siRNA controls (Fig. 4E,F), supporting the notion that this target is not responsible for dronedarone’s anti-cancer effects. The gene discussed is THRA; the disease is cancer.