SCD and metabolic syndrome: As well, we have found that insufficient or excessive status of calcium in early life has a long term effect on brain acretion of docosahexaenoic acid mediated by altered DNA methylation and associated expressions of fatty acid desaturases, and also a long lasting adverse effect on gut microbiota (unpublished data), which have been proved to be closely associated with dyslipidemia and related chronic diseases44,45.