CD8A and neoplasm: Given that C-ECM scores correlate with CD8 T cells and CYT (Fig. 2d and Supplementary Figure 2D, and the fact that C-ECM-up scores are adversely prognostic despite the positive prognostic impact of CYT9, we postulated that the C-ECM-up score may be enriched in immunologically ‘hot’ tumours and may reflect an adaptive mechanism of immune evasion.