MMRN1 and neoplasm: We then performed a Cox regression based on quartile-thresholded C-ECM scores with American Joint Committee on Cancer stage and tumour type as strata to examine the prognostic impact of this dysregulation; upregulated C-ECM genes were significantly associated with poor prognosis (Fig. 1c, d, hazard ratio (HR) = 1.73, p < 6.3e−7 for top versus bottom quartile, Cox regression, two sided) while downregulated C-ECM genes were not (Supplementary Figure 1G), suggesting that the variation we observed in C-ECM gene transcription is clinically relevant.