SIRT1 and colorectal carcinoma: SIRT1 rs10997870 TT, TG, and GG genotype frequencies did not differ between subcohort members and CRC cases (40.0, 47.2, and 12.8 percent in the male subcohort versus 41.4, 45.6, and 13.0 percent in male CRC cases; and 38.4, 47.6 and 14.0 percent in the female subcohort versus 39.5, 47.0, and 13.5 percent in female CRC cases).