SIRT1 and colorectal carcinoma: Comparison of SIRT1 rs12778366 TT, TC, and CC genotype frequencies between subcohort members and CRC cases showed that slightly more subcohort members than CRC cases carried one or two copies of the minor allele (72.8, 25.0, and 2.2 percent in the male subcohort versus 74.7, 23.6, and 1.7 percent in male CRC cases; and 71.4, 26.2, and 2.4 percent in the female subcohort versus 74.3, 24.3, and 1.4 in female CRC cases).