Similar associations with aggressive clinico-pathologic features were observed when evaluating P4HA2 mRNA level in the invasive tumours of the METABRIC series (n = 1980), for example with high tumour grade (p = 0.03), lymph node metastasis (p = 0.028), ER negativity (p = 0.0001), HER2 positivity (p < 0.0001) in addition to shorter breast cancer specific survival (BCSS) (HR = 1.3, 95%CI = 1.1–1.6, p = 0.002). The gene discussed is P4HA2; the disease is breast cancer.