High expression of P4HA2 within the malignant epithelial cells and/or surrounding stromal fibroblasts in the pure DCIS was associated with various clinicopathological parameters characteristic of high risk DCIS (Table 1) including younger age at diagnosis, DCIS presented symptomatically, high nuclear grade, presence of comedo necrosis, ER negativity, PR negativity, HER2 positivity, and triple negative DCIS. The gene discussed is P4HA2; the disease is ductal breast carcinoma in situ.