P4HA2 and cancer: P4HA2 is one of the key regulator enzymes for collagen biosynthesis, stabilisation, ECM remodelling and stiffness18 and has been reported to associate with poor outcome in many malignant tumours.19,20,23 Using the METABRIC cohort for robust molecular data in a large number of IBC showed associations between aggressive behaviour of IBC and higher levels of P4HA2 mRNA.