We also examined Tregs and found that the absolute number and percentage of CD4+Foxp3+ T cells in tumours were increased (Fig. 3h and Supplemental Fig. 11e), but the CD8+/Treg ratio was significantly higher after treatment with vvDD-IL-2-RG compared to other virus treatment (Fig. 3i). The gene discussed is FOXP3; the disease is neoplasm.