Nowakowski et al.22, in a control cohort of DLBCL patients treated with R-CHOP alone, obtained from Mayo Clinic Database, showed a 2y-PFS of 52%; while in our present cohort treated with R-CHOP in association to lenalidomide 5y-PFS in the whole DLBCL cohort was 63.5%. Here, DDIT3 is linked to diffuse large B-cell lymphoma.