PCDHA6 and neurodegenerative disease: The other genes identified by RNAseq to be altered with DISC1 exon 8 and exon 12 mutation are DPP10, PCDHA6, and ZNF506. DPP10 modulates the activity of Kv4.2 potassium channels, and has been implicated in mental illness and neurodegenerative disease models75–77 Decreased DPP10 expression suggests a possible synaptic phenotype not identified in the current study, which could be further investigated with detailed electrophysiological analyses.