Two of the BPH/LUTS variants discovered in our study have previously been reported to associate with risk of prostate cancer, i.e. rs2555019 (it has r2 = 0.81 with rs127088422) located downstream of TBX5 on 12q24.21, and rs11651052 (which has r2 = 0.91 with rs443079623) located intronic in HNF1B on 17q12. The gene discussed is TBX5; the disease is Familial prostate cancer.