VKORC1 and Alzheimer disease: The three variants indicating high risk ratios in Kuwaiti exomes for disease pathogenesis and response to medication were: the VKORC1 variant was associated with warfarin resistance (AD) (heterozygous in four individuals and homozygous recessive in one individual), the ABCA4 variant was associated with susceptibility to age-related macular degeneration (AD) (heterozygous in 12 individuals and homozygous recessive in one individual), and the LIPI variant was associated with susceptibility to hypertriglyceridemia (AD) (heterozygous in 10 individuals).