An interesting example of rare & deleterious “risk factor” variants associated with increasing risk for complex disorders was the GHRL variant (rs34911341-C/T; Arg51gln) which OMIM associated with susceptibility to the complex disorder of obesity (along with genes such as POMC, SDC3 and ADRB2); the variant was originally seen in 6.13% of 96 unrelated Swedish female subjects of morbid obesity (BMI 42.3 ± 3.4 Kg/m2)57. Here, SDC3 is linked to morbid obesity.