Previous studies have indicated that FBXL10 was a histone lysine demethylase that could target H3K4me3 or H3K36me2 for demethylation15,21; our results revealed that FBXL10 especially removed methyl groups from H3K4me3 in ovarian cancer cells (Fig. 5f). The gene discussed is KDM2B; the disease is ovarian carcinoma.