As these data hint at a profound impact of the neuroinflammatory environment on astrocyte phenotype, we sought to investigate the impact of three crucial cytokines in MS, i.e., interleukin-1β (IL-1β), TNF-α, and IL-6, at a transcriptomic level (Becher et al., 2017). The gene discussed is IL1B; the disease is myeloid sarcoma.