Given the present pamidronate-mediated rescuing of bilirubin-impaired mitochondrial apoptosis in SHED associated with AKT, ERK1/2, and suppressed NF-kB signal pathways, pamidronate treatment in pediatric patients with hyperbilirubinemia might prevent dentin hypoplasia. The gene discussed is AKT1; the disease is Hyperbilirubinemia.