Other work had previously indicated that blocking EGFR endocytosis enhances the efficacy of gefitinib towards EGFRWT NSCLC cells, with an endocytosis block and gefitinib combination significantly inhibiting growth both in vitro and in vivo, as well as prompting a large proportion of the cells to undergo apoptosis [24]. The gene discussed is EGFR; the disease is non-small cell lung carcinoma.