USP17 depletion significantly reduced A549 (Fig. 1D, G), HCC827 (Fig. 1E, H) and H1975 (Fig. 1F, I) cell numbers and viability, indicating that USP17 is required for the proliferation of NSCLC cells independent of the EGFR mutational status. Here, EGFR is linked to non-small cell lung carcinoma.