SOD2 and Hyperglycemia: Further, overexpression of UCP-1 has been shown to inhibit apoptotic caspase cleavage and activation in rat DRGs, a finding corroborated by recent data purporting that UCP-1 or MnSOD expression in aortic endothelial cells inhibits macrophage adhesion and inflammatory activity, peroxisome proliferator-activated receptor gamma activation, and hyperglycemia-associated eNOS activity [45].