Patients with ITP have been shown to exhibit abnormalities of CD4+ cells, including Th1 cell polarization, Th2 cell overactivation, Th17 cell derangement, Treg cell down-regulation, and Th1/Th2 or Th17/Treg imbalances [27–32]. This evidence concerns the gene CD4 and autoimmune thrombocytopenic purpura.