KHK and lactic acidosis: For instance, fructose has been shown to induce lactic acidosis, high blood pressure, de novo lipogenesis, oxidative stress, and impairment of insulin sensitivity.[8–13] Recent studies have emphasized the importance of the rapid metabolism of fructose in the liver by ketohexokinase (KHK) as the key mechanism driving fructose-induced adverse metabolic effects.[14–18]