SOCS3 and obesity due to melanocortin 4 receptor deficiency: Both IGF-2 and SOCS3 have been suggested to play a role in obesity development [34] and in the regulation of insulin resistance [35], allowing us to speculate that the higher levels of miR-483-5p may interplay with IGF-2 and/or SOCS3 and thereby contribute to obesity, insulin resistance and risk of diabetes development.