XRCC1 and hepatocellular carcinoma: However, Zeng et al. [12] suggested that XRCC1 Arg194Trp, Arg280His, and Arg399Gln are not predisposing factors for HCC but found that there was an additive interaction between XRCC1 polymorphisms and smoking, drinking, and chronic hepatitis B virus (HBV) infection.