Cancer cells adopt several types of motility modes: (1) mesenchymal type and lamellipodia mode with elongated morphology directed by Rac signals, (2) blebbing and amoeboid mode with small F-actin-rich protrusions regulated by Rho-kinase signaling [12,53], and (3) collective invasion of tumor cell clusters, with leading cells expressing basal epithelial markers such as cytokeratin-14 or p63 [54,55]. This evidence concerns the gene AKT1 and cancer.