The tripartite motif (TRIM) protein family of E3 ubiquitin ligases is intimately implicated in tumorigenesis by enhancing gene translocation and fusion [1,2], promoting cell cycle arrest through deregulation of tumor protein 53 (p53) and cyclin-dependent kinase (CDK) inhibitors degradation [3,4], or regulating tumor metabolic homeostasis with melanoma antigen family proteins [5]. The gene discussed is TP53; the disease is neoplasm.