Notably, TRIM59 protein levels were positively correlated with the pathologic grades of breast cancer (Grade I, n = 18; Grade I–II, n = 26; Grade II and higher, n = 110) and were slightly higher in estrogen receptor (ER)-negative breast cancer (Figs 1D and S1E–S1G and S1 and S2 Tables). Here, ESR1 is linked to breast carcinoma.