The TRIM family proteins, most of which have E3 Ub ligase activity, play crucial roles in (i) cancer cell metabolism by regulating adenosine monophosphate (AMP)-activated protein kinase (AMPK) stability [5], (ii) cancer cell proliferation and apoptosis by targeting p53 [4], and (iii) oncogenic transcriptional activation [52]. The gene discussed is WEE1; the disease is cancer.