TRIM59 stabilizes PDCD10 by preventing its lysine (K) 63 ubiquitination induced by RNFT1 and the subsequent phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa (p62)-selective autophagic degradation, thereby augmenting its suppressive effects on RhoA/ROCK1-mediated mesenchymal-amoeboid transition (MAT) in breast tumor. This evidence concerns the gene TRIM59 and breast neoplasm.