In TRIM59-depleted MCF7 cells, we also observed down-regulation of pro-oncogenic factors, such as avian myelocytomatosis virus oncogene cellular homolog (c-Myc), type I insulin-like growth factor receptor (IGF1R), and vascular endothelial growth factor receptor 2 (VEGFR2), along with enhanced expression of E-cadherin (encoded by cadherin 1 [Cdh1]) and inositol polyphosphate-4-phosphatase type II b (INPP4b), a recently discovered tumor suppressor [25–27] (S2C Fig). Here, MYC is linked to neoplasm.