PDCD10 and breast neoplasm: TRIM59 stabilizes PDCD10 by preventing its lysine (K) 63 ubiquitination induced by RNFT1 and the subsequent phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa (p62)-selective autophagic degradation, thereby augmenting its suppressive effects on RhoA/ROCK1-mediated mesenchymal-amoeboid transition (MAT) in breast tumor.