Several lines of evidence have implicated critical roles of PDCD10 in the suppression of ROCK/Rho signaling-mediated phosphorylation of MLC to regulate actomyosin contractility [15–17], whose expression is aberrantly up-regulated in metastatic colon cancer cells [57] and pancreatic adenocarcinomas [58]. This evidence concerns the gene MLC1 and pancreatic adenocarcinoma.