AKT1 and breast cancer: TRIM59 depletion in breast cancer cells could further impinge on genes and pathways involved in cancer metabolism: (1) down-regulation of metabolism-related oncogenes such as c-MYC and IGF1R [67,68]; (2) up-regulation of tumor suppressors INPP4b, a PtdIns(3,4,5) P3 phosphatase that modulates membrane lipid metabolism and inhibits protein kinase B (AKT) activation [69].