It currently includes 42 conditions with orphacodes that are organised into eight broad categories termed ‘Main Thematic Groups (MTGs)’ which include Adrenal Disorders, Disorders of Calcium and Phosphate Homeostasis, Genetic Disorders of Glucose and Insulin Homeostasis, Genetic Endocrine Tumour Syndromes, Growth and Genetic Obesity Syndromes, Pituitary Disorders, Sex Development and Maturation Disorders and Thyroid Disorders. The gene discussed is INS; the disease is hereditary disease.