CRELD1 and familial atrioventricular septal defect: Allelic interactions between CRELD1 and VEGFA (vascular endothelial growth factor-A) contribute to AVSD (Redig et al., 2014) and it was proposed that CRELD1 is required for VEGF-dependent proliferation of endocardial cells by promoting expression of NFATc1 target genes (Mass et al., 2014).