Considering the potential benefit of M2 macrophage cell therapy on DKD it is important to note that M2 macrophages have anti‐inflammatory properties but are also associated with fibrosis as they can secrete TGF‐β.19, 20 Therefore, in our study we found that in mice treated either with BM‐ΦM2, Φ‐BM and Φ‐RAW infusion, the renal TGFβ‐1 as well as renal fibrosis were similar to that observed in diabetic non‐treated animals. The gene discussed is TGFB1; the disease is renal fibrosis.