The previous studies have demonstrated that Rdx (SPOP homologue) binds and ubiquitinates Ci (GLI2/3 homologue) to inhibit Hh signalling activity in Drosophila. 14 We tried to test whether SPOP destabilizes GLI2/3 to negatively regulate Hh pathway in NSCLC cells. This evidence concerns the gene GLI2 and non-small cell lung carcinoma.