TGFβ can (although not always)103 perform an anti-inflammatory role, including inhibition of cytokine production from macrophages104 and inhibition of B-lymphocyte proliferation.105 Thus, patients with an impaired TGFβ-mediated immune response could potentially be vulnerable to proinflammatory effects that characterize psychosis (ie, homogenous increases in IL6). The gene discussed is IL6; the disease is psychotic disorder.