PRL and erectile dysfunction: Prolactin (PRL)-secreting pituitary adenomas are the most common functional pituitary adenoma and account for ∼45% of all pituitary adenomas.[1,2] In general, prolactinomas occur in females more frequently than males,[3] and are diagnosed due to more obvious clinical manifestations, such as amenorrhea-lactation syndrome; whereas the clinical symptoms in men, such as sexual impotence and a decreased libido, are frequently missed.