Factors that increase the risk of lithium toxicity include renal insufficiency, overdose, volume depletion, infections, decreased effective circulating volume (cirrhosis, congestive heart failure, and nephrotic syndrome), medication interaction (e.g., diuretics and angiotensin-converting enzyme inhibitor), gastroenteritis, and anorexia.[1,7–9]. This evidence concerns the gene ACE and Renal insufficiency.