CD46 and melanoma: In addition, they evaluated 22 different adenovirus types, among which Ad35 had the highest internalization efficiency in short‐term cultures of melanoma cells.32 Takagi et al21 showed that CD46‐overexpressing cells had a significantly higher response to Ad35 fiber modification of oncolytic adenovirus and could improve viral infectivity and enhance antitumor efficacy in malignant mesothelioma cells, especially in those with low CAR expression.