MT-ND5 and Leigh syndrome: Studies have shown the ability of both mtZFNs and mtTALENs to selectively eliminate mutant mtDNA in cell lines harboring a number of pathogenic mutations, including the mtDNA point mutations m.8993T > G (associated with neuropathy, ataxia, and retinitis pigmentosa (NARP)), m.8344A > G (associated with myoclonic epilepsy with ragged-red fibers (MERRF)), m.13513A > G MT-ND5 mutation (associated with MELAS and Leigh syndrome (LS)) and also the “common deletion” m.8483-1345del4977 (associated with CPEO and Kearns–Sayre syndrome (KSS)).