ADAMTS10 and ADAMTS17 both contribute to formation and function of fibrillin-1 microfibrils (Kutz et al., 2011; Hubmacher and Apte, 2015; Hubmacher et al., 2017), leading us to form the hypothesis that microfibril defects can cause glaucoma (Kuchtey and Kuchtey, 2014). The gene discussed is ADAMTS10; the disease is glaucoma.