Other genes involved in microfibril function, such as LOXL1 (Thorleifsson et al., 2007) and LTBP2 (Ali et al., 2009; Narooie-Nejad et al., 2009; Kuehn et al., 2011), are associated with human glaucoma, lending further support to our microfibril hypothesis of glaucoma. This evidence concerns the gene LOXL1 and glaucoma.