TGFB1 and glaucoma: In addition to their structural roles, microfibrils act as a depot for latent transforming growth factor-β (TGFβ) and bone morphogenetic protein (BMP), thereby playing a central role in the localization and regulation of signal transduction via TGFβ superfamily members (Ramirez and Rifkin, 2009; Horiguchi et al., 2012), which is particularly relevant since multiple studies implicate TGFβ in glaucoma pathogenesis (Fuchshofer and Tamm, 2012).