CTSK and osteoporosis: The effectiveness of pharmacological cathepsin K inhibition as a treatment for bone diseases such as osteoporosis and osteoarthritis has been demonstrated in the literature (Sims and Ng, 2014; Bandeira and Bilezikian, 2017; Zhuo et al., 2014; Masarachia et al., 2012; Williams et al., 2013; Paschalis et al., 2017).