In mouse melanoma cell lines, CEACAM1-4L isoform downregulates cell surface levels of NKG2D ligands MICA and ULBP2 [45] while CEACAM1-3S and -3L overexpressions in CRC cell lines cause sequestration of MICA/B intracellularly, preventing it from activating NK cells [44]. The gene discussed is MICA; the disease is colorectal carcinoma.