They developed a unique trimeric PD-L1 trap protein by genetically fusing the extracellular domain of PD-1 with a robust trimerization domain from the cartilage matrix protein through an optimized hinge linker and demonstrated that oxaliplatin (OxP) boosts anti-PD-L1 mAb therapy against murine colorectal cancer. This evidence concerns the gene CD274 and colorectal cancer.